Tori is on systemic antifungal for tinea infection. You are aware that the antifungals may cause:

The correct choice highlights hepatotoxicity as a potential adverse effect of systemic antifungals, which is critical to consider in the management of patients treated for fungal infections. Many systemic antifungals, such as azoles (like fluconazole and itraconazole) and allylamines (like terbinafine), can lead to liver enzyme elevation and hepatotoxicity. This is particularly important to monitor, as liver dysfunction may not present with noticeable symptoms until significant damage has occurred.

Patients on systemic antifungal therapy should undergo regular liver function tests during treatment to ensure that any signs of hepatotoxicity are detected early. Understanding this side effect is essential for safe prescribing and for ensuring patient safety throughout the treatment process.

Other options do present potential issues in different contexts. For instance, while skin discoloration can occur with some topical treatments, it is not a common or direct consequence of systemic antifungals. Breathing difficulties are generally more associated with allergic reactions or anaphylaxis related to medication but are not a primary concern with antifungals. Similarly, renal failure is not typically a common side effect of systemic antifungal agents, although some specific antifungals may require caution in patients with pre-existing renal issues. Thus, focusing on the hepatotoxicity