A delayed serum sickness-type reaction from multiple insect stings can be managed with what medication?

A delayed serum sickness-type reaction is characterized by symptoms such as fever, rash, and arthralgia that occur days to weeks after exposure, such as from multiple insect stings. The management of such reactions often involves addressing the underlying inflammation and immune response.

Corticosteroids like prednisone are effective because they have potent anti-inflammatory and immunosuppressive properties. By using a tapered course of corticosteroids, the inflammatory response can be controlled progressively, minimizing potential withdrawal effects while alleviating symptoms of the reaction. This method is particularly important in managing delayed hypersensitivity reactions, where the goal is to reduce inflammation and symptomatic relief.

For other treatment alternatives, options that might target immediate allergic responses, like epinephrine or antihistamines, are not appropriate for delayed serum sickness as they are designed for acute reactions rather than for managing an immune response that has already taken place. Thus, a corticosteroid is the most suitable choice for managing the delayed symptoms associated with multiple insect stings in this context.